Rapid accurate mass desorption electrospray ionisation tandem mass spectrometry of pharmaceutical samples

Jonathan P. Williams, James Scrivens

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)

Abstract

Desorption electrospray ionisation (DESI) has been successfully combined with a hybrid quadrupole time-of-flight mass spectrometer to provide mass spectra and product ion mass spectra of active ingredients formulated in pharmaceutical tablets, gels and ointments. Accurate mass data has been obtained from the DESI mass spectra and of the product ion fragments of selected ions, greatly enhancing the selectivity and information content of the experiment. This accurate mass information only takes seconds to acquire since the DESI technique does not require any sample preparation or extraction prior to mass analysis.

Original languageEnglish
Pages (from-to)3643-3650
Number of pages8
JournalRapid Communications in Mass Spectrometry
Volume19
Issue number24
DOIs
Publication statusPublished - 27 Dec 2005

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Electrospray ionization
Mass spectrometry
Desorption
Ions
Pharmaceutical Preparations
Mass spectrometers
Ointments
Tablets
Gels
Experiments

Cite this

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Rapid accurate mass desorption electrospray ionisation tandem mass spectrometry of pharmaceutical samples. / Williams, Jonathan P.; Scrivens, James .

In: Rapid Communications in Mass Spectrometry, Vol. 19, No. 24, 27.12.2005, p. 3643-3650.

Research output: Contribution to journalArticleResearchpeer-review

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