Rapid accurate mass desorption electrospray ionisation tandem mass spectrometry of pharmaceutical samples

Jonathan P. Williams, James Scrivens

    Research output: Contribution to journalArticle

    129 Citations (Scopus)

    Abstract

    Desorption electrospray ionisation (DESI) has been successfully combined with a hybrid quadrupole time-of-flight mass spectrometer to provide mass spectra and product ion mass spectra of active ingredients formulated in pharmaceutical tablets, gels and ointments. Accurate mass data has been obtained from the DESI mass spectra and of the product ion fragments of selected ions, greatly enhancing the selectivity and information content of the experiment. This accurate mass information only takes seconds to acquire since the DESI technique does not require any sample preparation or extraction prior to mass analysis.

    Original languageEnglish
    Pages (from-to)3643-3650
    Number of pages8
    JournalRapid Communications in Mass Spectrometry
    Volume19
    Issue number24
    DOIs
    Publication statusPublished - 27 Dec 2005

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