Rational design for over-production of desirable microbial metabolites by precision engineering

Hong Gao, Xianlong Zhou, Zhongxuan Gou, Ying Zhuo, Chengzhang Fu, Mei Liu, Fuhang Song, Elizabeth Ashforth, Lixin Zhang

    Research output: Contribution to journalReview article

    Abstract

    Microbes represent a valuable source of commercially significant natural products that have improved our quality of life. Precision engineering can be used to precisely identify and specifically modify genes responsible for production of natural products and improve this production or modify the genes creating products that would not otherwise be produced. There have been several success stories concerning the manipulation of regulatory genes, pathways, and genomes to increase the productivity of industrial microbes. This review will focus on the strategies and integrated approaches for precisely deciphering regulatory genes by various modern techniques. The applications of precision engineering in rational strain improvement also shed light on the biology of natural microbial systems.

    Original languageEnglish
    Pages (from-to)151-63
    Number of pages13
    JournalAntonie van Leeuwenhoek
    Volume98
    Issue number2
    DOIs
    Publication statusPublished - Aug 2010

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  • Cite this

    Gao, H., Zhou, X., Gou, Z., Zhuo, Y., Fu, C., Liu, M., Song, F., Ashforth, E., & Zhang, L. (2010). Rational design for over-production of desirable microbial metabolites by precision engineering. Antonie van Leeuwenhoek, 98(2), 151-63. https://doi.org/10.1007/s10482-010-9442-4