Rational design for over-production of desirable microbial metabolites by precision engineering

Hong Gao, Xianlong Zhou, Zhongxuan Gou, Ying Zhuo, Chengzhang Fu, Mei Liu, Fuhang Song, Elizabeth Ashforth, Lixin Zhang

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Microbes represent a valuable source of commercially significant natural products that have improved our quality of life. Precision engineering can be used to precisely identify and specifically modify genes responsible for production of natural products and improve this production or modify the genes creating products that would not otherwise be produced. There have been several success stories concerning the manipulation of regulatory genes, pathways, and genomes to increase the productivity of industrial microbes. This review will focus on the strategies and integrated approaches for precisely deciphering regulatory genes by various modern techniques. The applications of precision engineering in rational strain improvement also shed light on the biology of natural microbial systems.

Original languageEnglish
Pages (from-to)151-63
Number of pages13
JournalAntonie van Leeuwenhoek
Volume98
Issue number2
DOIs
Publication statusPublished - Aug 2010

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Regulator Genes
Biological Products
Genes
Quality of Life
Genome

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Gao, Hong ; Zhou, Xianlong ; Gou, Zhongxuan ; Zhuo, Ying ; Fu, Chengzhang ; Liu, Mei ; Song, Fuhang ; Ashforth, Elizabeth ; Zhang, Lixin. / Rational design for over-production of desirable microbial metabolites by precision engineering. In: Antonie van Leeuwenhoek. 2010 ; Vol. 98, No. 2. pp. 151-63.
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Gao, H, Zhou, X, Gou, Z, Zhuo, Y, Fu, C, Liu, M, Song, F, Ashforth, E & Zhang, L 2010, 'Rational design for over-production of desirable microbial metabolites by precision engineering', Antonie van Leeuwenhoek, vol. 98, no. 2, pp. 151-63. https://doi.org/10.1007/s10482-010-9442-4

Rational design for over-production of desirable microbial metabolites by precision engineering. / Gao, Hong; Zhou, Xianlong; Gou, Zhongxuan; Zhuo, Ying; Fu, Chengzhang; Liu, Mei; Song, Fuhang; Ashforth, Elizabeth; Zhang, Lixin.

In: Antonie van Leeuwenhoek, Vol. 98, No. 2, 08.2010, p. 151-63.

Research output: Contribution to journalReview articleResearchpeer-review

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AU - Gao, Hong

AU - Zhou, Xianlong

AU - Gou, Zhongxuan

AU - Zhuo, Ying

AU - Fu, Chengzhang

AU - Liu, Mei

AU - Song, Fuhang

AU - Ashforth, Elizabeth

AU - Zhang, Lixin

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AB - Microbes represent a valuable source of commercially significant natural products that have improved our quality of life. Precision engineering can be used to precisely identify and specifically modify genes responsible for production of natural products and improve this production or modify the genes creating products that would not otherwise be produced. There have been several success stories concerning the manipulation of regulatory genes, pathways, and genomes to increase the productivity of industrial microbes. This review will focus on the strategies and integrated approaches for precisely deciphering regulatory genes by various modern techniques. The applications of precision engineering in rational strain improvement also shed light on the biology of natural microbial systems.

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