Rational design for over-production of desirable microbial metabolites by precision engineering

Hong Gao; Xianlong Zhou; Zhongxuan Gou; Ying Zhuo; Chengzhang Fu; Mei Liu; Fuhang Song; Elizabeth Ashforth; Lixin Zhang

doi:10.1007/s10482-010-9442-4

Rational design for over-production of desirable microbial metabolites by precision engineering

Hong Gao, Xianlong Zhou, Zhongxuan Gou, Ying Zhuo, Chengzhang Fu, Mei Liu, Fuhang Song, Elizabeth Ashforth, Lixin Zhang

Research output: Contribution to journal › Review article › peer-review

Abstract

Microbes represent a valuable source of commercially significant natural products that have improved our quality of life. Precision engineering can be used to precisely identify and specifically modify genes responsible for production of natural products and improve this production or modify the genes creating products that would not otherwise be produced. There have been several success stories concerning the manipulation of regulatory genes, pathways, and genomes to increase the productivity of industrial microbes. This review will focus on the strategies and integrated approaches for precisely deciphering regulatory genes by various modern techniques. The applications of precision engineering in rational strain improvement also shed light on the biology of natural microbial systems.

Original language	English
Pages (from-to)	151-63
Number of pages	13
Journal	Antonie van Leeuwenhoek
Volume	98
Issue number	2
DOIs	https://doi.org/10.1007/s10482-010-9442-4
Publication status	Published - Aug 2010

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title = "Rational design for over-production of desirable microbial metabolites by precision engineering",

abstract = "Microbes represent a valuable source of commercially significant natural products that have improved our quality of life. Precision engineering can be used to precisely identify and specifically modify genes responsible for production of natural products and improve this production or modify the genes creating products that would not otherwise be produced. There have been several success stories concerning the manipulation of regulatory genes, pathways, and genomes to increase the productivity of industrial microbes. This review will focus on the strategies and integrated approaches for precisely deciphering regulatory genes by various modern techniques. The applications of precision engineering in rational strain improvement also shed light on the biology of natural microbial systems.",

author = "Hong Gao and Xianlong Zhou and Zhongxuan Gou and Ying Zhuo and Chengzhang Fu and Mei Liu and Fuhang Song and Elizabeth Ashforth and Lixin Zhang",

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T1 - Rational design for over-production of desirable microbial metabolites by precision engineering

AU - Gao, Hong

AU - Zhou, Xianlong

AU - Gou, Zhongxuan

AU - Zhuo, Ying

AU - Fu, Chengzhang

AU - Liu, Mei

AU - Song, Fuhang

AU - Ashforth, Elizabeth

AU - Zhang, Lixin

PY - 2010/8

Y1 - 2010/8

N2 - Microbes represent a valuable source of commercially significant natural products that have improved our quality of life. Precision engineering can be used to precisely identify and specifically modify genes responsible for production of natural products and improve this production or modify the genes creating products that would not otherwise be produced. There have been several success stories concerning the manipulation of regulatory genes, pathways, and genomes to increase the productivity of industrial microbes. This review will focus on the strategies and integrated approaches for precisely deciphering regulatory genes by various modern techniques. The applications of precision engineering in rational strain improvement also shed light on the biology of natural microbial systems.

AB - Microbes represent a valuable source of commercially significant natural products that have improved our quality of life. Precision engineering can be used to precisely identify and specifically modify genes responsible for production of natural products and improve this production or modify the genes creating products that would not otherwise be produced. There have been several success stories concerning the manipulation of regulatory genes, pathways, and genomes to increase the productivity of industrial microbes. This review will focus on the strategies and integrated approaches for precisely deciphering regulatory genes by various modern techniques. The applications of precision engineering in rational strain improvement also shed light on the biology of natural microbial systems.

U2 - 10.1007/s10482-010-9442-4

DO - 10.1007/s10482-010-9442-4

M3 - Review article

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SP - 151

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JO - Antonie van Leeuwenhoek

JF - Antonie van Leeuwenhoek

IS - 2

ER -

Rational design for over-production of desirable microbial metabolites by precision engineering

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