Regulation of phagosome functions by post-translational modifications: a new paradigm

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Phagosomes are highly dynamic organelles formed by the uptake of particles through phagocytic innate immune cells such as macrophages. Their key roles in microbe elimination and antigen presentation make them essential for innate and adaptive immunity. However, phagosomes are also important for tissue homeostasis as even in healthy individuals billions of dead cells are phagocytosed each day. In this short review, we highlight how the use of latex beads as inert baits for phagocytosis and subsequent analysis by proteomics has changed our understanding of the phagosome. We further discuss recent data on post-translational modifications such as phosphorylation and ubiquitylation that regulate phagosome functions and demonstrate that the phagosome is not only a 'degradative organelle' but also serves as a subcellular signalling platform.
Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume48
Early online date24 Nov 2018
DOIs
Publication statusPublished - 1 Feb 2019

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phagosomes
post-translational modification
organelles
antigen presentation
latex
phagocytosis
baits
proteomics
homeostasis
phosphorylation
macrophages
cells
microorganisms
uptake mechanisms

Cite this

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Regulation of phagosome functions by post-translational modifications: a new paradigm. / Dean, Paul.

In: Current Opinion in Chemical Biology, Vol. 48, 01.02.2019, p. 73-80.

Research output: Contribution to journalArticleResearchpeer-review

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