Satellite cells depletion in exercising human skeletal muscle is restored by ginseng component Rg1 supplementation

Jinfu Wu, Suchada Saovieng, I-Shiung Cheng, Jørgen Jensen, Wei-Horng Jean, Ahmad Alkhatib, Chung-Lan Kao, Chih-Yang Huang, Chia-Hua Kuo

Research output: Contribution to journalArticlepeer-review

Abstract

Rg1 is a steroidal component in Panax ginseng, which increases high intensity exercise performance in humans. Here, we examined the effects of Rg1 supplementation on the dynamical changes of human muscle satellite cells following exercise. Twelve young men ingested Rg1 (5 mg) or Placebo (PLA) 1 h before exercise in a double-blind, placebo-controlled crossover design. Biopsy muscles were collected before, immediately after, and 3 h post-exercise. TNF-α mRNA increased and satellite cell number decreased immediately after exercise, followed by decreases in centrally nucleated myofibers and total glutathione 3 h post-exercise. Rg1 supplementation increased Myf5 mRNA and restored satellite cell number after exercise, and total glutathione and centrally nucleated myofibers 3 h post exercise. Rg1 had no significant effect on TNF-α mRNA response against exercise. The transient exercise response in suppressed centronucleation and satellite cell depletion which are reversed by Rg1 are not associated with TNF-α expression.
Original languageEnglish
Pages (from-to)27-33
JournalJournal of Functional Foods
Volume58
Early online date29 Apr 2019
DOIs
Publication statusPublished - Jul 2019

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