Abstract
Sedentary time (ST) and light-intensity physical activity (LIPA) are movement behaviours associated with important health outcomes, but are not widely explored in respiratory diseases. We aimed to describe their volume and/or accumulation patterns in moderate-severe COPD, bronchiectasis and severe asthma using the accurate postural-based accelerometer activPAL, contrasting these values with a non-respiratory population. We also sought to test the cross-sectional associations of these behaviours with disease characteristics by diagnostic group, and as a combined label-free disease group. Results: Adults with COPD (n = 64), bronchiectasis (n = 61), severe asthma (n = 27), and controls (n = 61) underwent cross-sectional measurements of volume and/or accumulation patterns of ST and LIPA. The prevalence and characteristics, and associations with exercise capacity, health-status, airflow-limitation, dyspnoea, systemic inflammation and exacerbations were analysed. ST volumes in COPD were higher than that of bronchiectasis and severe asthma. Values in bronchiectasis and severe asthma were similar to each other and controls (≈8.9 h/day). Their accumulation patterns were also significantly better than in COPD, but similar if not worse compared to controls. LIPA volumes in bronchiectasis and severe asthma were also higher than those of COPD (p < 0.05) and controls. In bronchiectasis and COPD, lower levels/better patterns of ST accumulation, as well as higher LIPA volume were associated with better clinical characteristics. These associations may be mediated by airflow limitation. Conclusions: The discordance between engagement in ST volume versus ST patterns highlights the importance of accounting for both these different yet complementary metrics. ST and LIPA are low-intensity activities associated with important clinical characteristics in people with chronic respiratory diseases. Trial registration: Not applicable.
| Original language | English |
|---|---|
| Article number | 106367 |
| Journal | Respiratory Medicine |
| Volume | 181 |
| Early online date | 5 Apr 2021 |
| DOIs | |
| Publication status | Published - 1 May 2021 |
Bibliographical note
Funding Information:Dr. PG Gibson reports personal fees from AstraZeneca , GlaxoSmithKline , Novartis , grants from AstraZeneca , GlaxoSmithKline , outside the submitted work.
Funding Information:
Adults (?18yrs; no-exacerbation 4-weeks pre-assessment) with physician-diagnosed moderate-severe COPD [15], severe asthma [16], bronchiectasis [17] and non-respiratory controls were recruited for a cross-sectional study via the research databases of the Hunter Medical Research Institute and the Department of Respiratory Medicine, John Hunter Hospital (Newcastle, Australia). The Human Research Ethics Committee of the Hunter New England Local Health District granted Ethics approval. Participants provided informed written consent.Dr. PG Gibson reports personal fees from AstraZeneca, GlaxoSmithKline, Novartis, grants from AstraZeneca, GlaxoSmithKline, outside the submitted work.Dr. VM McDonald reports grants and personal fees from GlaxoSmithKline, grants and personal fees from AstraZeneca, personal fees from Menarini, outside the submitted work.This research was supported by a University of Newcastle and Priority Research Centre for Healthy Lungs postgraduate scholarship; a John Hunter Hospital Charitable Trust Grant and the Hunter Medical Research Institute, Australia.
Publisher Copyright:
© 2021 Elsevier Ltd