Small molecule probes that target Abl kinase

Karunakaran A. Kalesh; Derek S. B. Sim; Jigang Wang; Kai Liu; Qingsong Lin; Shao Q. Yao

doi:10.1039/b919888a

Small molecule probes that target Abl kinase

Karunakaran A. Kalesh, Derek S. B. Sim, Jigang Wang, Kai Liu, Qingsong Lin, Shao Q. Yao

Research output: Contribution to journal › Article › peer-review

Abstract

Two different strategies, namely a dialdehyde-based cross-linking and photo-affinity labeling, have been developed to generate small molecule activity-based probes (ABPs) for the Abelson (Abl) tyrosine kinase, of which probe 13, derived from the photo-affinity approach, showed specific labeling of Abl kinase present in a crude mammalian proteome.

Original language	English
Pages (from-to)	1118-1120
Number of pages	3
Journal	Chemical Communications
Volume	46
DOIs	https://doi.org/10.1039/b919888a
Publication status	Published - 14 Dec 2009
Externally published	Yes

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title = "Small molecule probes that target Abl kinase",

abstract = "Two different strategies, namely a dialdehyde-based cross-linking and photo-affinity labeling, have been developed to generate small molecule activity-based probes (ABPs) for the Abelson (Abl) tyrosine kinase, of which probe 13, derived from the photo-affinity approach, showed specific labeling of Abl kinase present in a crude mammalian proteome.",

author = "Kalesh, {Karunakaran A.} and Sim, {Derek S. B.} and Jigang Wang and Kai Liu and Qingsong Lin and Yao, {Shao Q.}",

year = "2009",

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doi = "10.1039/b919888a",

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AU - Kalesh, Karunakaran A.

AU - Sim, Derek S. B.

AU - Wang, Jigang

AU - Liu, Kai

AU - Lin, Qingsong

AU - Yao, Shao Q.

PY - 2009/12/14

Y1 - 2009/12/14

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AB - Two different strategies, namely a dialdehyde-based cross-linking and photo-affinity labeling, have been developed to generate small molecule activity-based probes (ABPs) for the Abelson (Abl) tyrosine kinase, of which probe 13, derived from the photo-affinity approach, showed specific labeling of Abl kinase present in a crude mammalian proteome.

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M3 - Article

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JF - Chemical Communications

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Small molecule probes that target Abl kinase

Abstract

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