Small molecule probes that target Abl kinase

Karunakaran A. Kalesh, Derek S. B. Sim, Jigang Wang, Kai Liu, Qingsong Lin, Shao Q. Yao

Research output: Contribution to journalArticlepeer-review


Two different strategies, namely a dialdehyde-based cross-linking and photo-affinity labeling, have been developed to generate small molecule activity-based probes (ABPs) for the Abelson (Abl) tyrosine kinase, of which probe 13, derived from the photo-affinity approach, showed specific labeling of Abl kinase present in a crude mammalian proteome.

Original languageEnglish
Pages (from-to)1118-1120
Number of pages3
JournalChemical Communications
Publication statusPublished - 14 Dec 2009
Externally publishedYes


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