Sphingolipid and ceramide homeostasis: Potential therapeutic targets

Simon A. Young, John G. Mina, Paul W. Denny, Terry K. Smith

    Research output: Contribution to journalReview article

    26 Citations (Scopus)

    Abstract

    Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has led to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer's disease, and numerous important human pathogens. In this paper we outline the major pathways in eukaryotic sphingolipid metabolism and discuss these in relation to disease and therapy for both chronic and infectious conditions.

    Original languageEnglish
    Article number248135
    JournalBiochemistry Research International
    DOIs
    Publication statusPublished - 21 Mar 2012

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