Structural analysis of synthetic polymer mixtures using ion mobility and tandem mass spectrometry

Gillian R. Hilton, Anthony T. Jackson, Konstantinos Thalassinos, James Scrivens

    Research output: Contribution to journalArticle

    52 Citations (Scopus)

    Abstract

    Ion mobility (IM) combined with tandem mass spectrometry (MS/MS) has been employed to separate and differentiate between polyether oligomers with the same nominal molecular weights. Poly(ethylene glycol)s with the same nominal mass-to-charge ratio (m/z), but with differing structures, were separated using ion mobility. IMMS/MS data were able to aid identification of the backbone and end groups of the four individual polyethers in the two sets of isobaric mixtures. The MS/MS data from the resolved oligomers enabled a detailed structural characterization of the polyether mixtures to be completed in one experiment.

    Original languageEnglish
    Pages (from-to)9720-9725
    Number of pages6
    JournalAnalytical Chemistry
    Volume80
    Issue number24
    DOIs
    Publication statusPublished - 15 Dec 2008

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