Meme automaton is an adaptive entity that autonomously acquires increasing level of capability and intelligence through embedded memes evolving independently or via social interactions. This paper embarks a study on memetic multiagent system (MeMAS) towards human-like social agents with memetic automaton. We introduce a potentially rich meme-inspired design and operational model, with Darwin’s theory of natural selection and Dawkins’ notion of a meme as the principal driving forces behind interactions among agents, whereby memes form the fundamental building blocks of the agents’ mind universe. To improve the efficiency and scalability of MeMAS, we propose memetic agents with structured memes in the present paper. Particularly, we focus on meme selection design where the commonly used elitist strategy is further improved by assimilating the notion of like-attracts-like in the human learning. We conduct experimental study on multiple problem domains and show performance of the proposed MeMAS on human-like social behavior.