Abstract
A new strategy for the synthesis of 2,3,5-trisbustituted furans from α-formylketene dithioacetals is described. The protocol involves a facile conversion of α-formylketene dithioacetals to vinylketene dithioacetals via Wittig reaction and subsequent N-bromosuccinimide-mediated cyclization to 2,3,5-trisbustituted furans. Further conversion of the 2-thioalkylfurans thus obtained to 2-aminofurans shows the potential synthetic utility of this new approach.
Original language | English |
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Pages (from-to) | 1667-1669 |
Journal | Tetrahedron Letters |
DOIs | |
Publication status | Published - 3 Feb 2011 |