Synthesis of 2,3,5-trisubstituted furans from a-formylaroylketene dithioacetals

K. A. Sasikala, K. A. Kalesh, E. R. Anabha, P. Madhavan Pillai, C. V. Asokan, K. S. Devaky

Research output: Contribution to journalArticlepeer-review


A new strategy for the synthesis of 2,3,5-trisbustituted furans from α-formylketene dithioacetals is described. The protocol involves a facile conversion of α-formylketene dithioacetals to vinylketene dithioacetals via Wittig reaction and subsequent N-bromosuccinimide-mediated cyclization to 2,3,5-trisbustituted furans. Further conversion of the 2-thioalkylfurans thus obtained to 2-aminofurans shows the potential synthetic utility of this new approach.
Original languageEnglish
Pages (from-to)1667-1669
JournalTetrahedron Letters
Publication statusPublished - 3 Feb 2011


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