The compass to follow: Focal adhesion turnover

Manos Mavrakis; M. Angeles Juanes

doi:10.1016/j.ceb.2023.102152

The compass to follow: Focal adhesion turnover

Manos Mavrakis, M. Angeles Juanes

Centre for Biodiscovery

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Abstract

How cells move is a fundamental biological question. The directionality of adherent migrating cells depends on the assembly and disassembly (turnover) of focal adhesions (FAs). FAs are micron-sized actin-based structures that link cells to the extracellular matrix. Traditionally, microtubules have been considered key to triggering FA turnover. Through the years, advancements in biochemistry, biophysics, and bioimaging tools have been invaluable for many research groups to unravel a variety of mechanisms and molecular players that contribute to FA turnover, beyond microtubules. Here, we discuss recent discoveries of key molecular players that affect the dynamics and organization of the actin cytoskeleton to enable timely FA turnover and consequently proper directed cell migration.

Original language	English
Article number	102152
Number of pages	17
Journal	Current Opinion in Cell Biology
Volume	80
DOIs	https://doi.org/10.1016/j.ceb.2023.102152
Publication status	Published - 1 Feb 2023

Bibliographical note

Funding Information:
This work was supported by grants from the Academy of Medical Science (AMS), Wellcome Trust/the Government Department of Business, Energy and Industrial Strategy/the British Heart Foundation/Diabetes UK, AMS Springboard Award (UK) [ SBF006\1070 ]; and the CIDEGENT Excellent Research Program of the Valencian Regional government (Spain) CIDEGENT/2021/026 to M.A.J.

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© 2023 The Author(s)

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Cite this

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abstract = "How cells move is a fundamental biological question. The directionality of adherent migrating cells depends on the assembly and disassembly (turnover) of focal adhesions (FAs). FAs are micron-sized actin-based structures that link cells to the extracellular matrix. Traditionally, microtubules have been considered key to triggering FA turnover. Through the years, advancements in biochemistry, biophysics, and bioimaging tools have been invaluable for many research groups to unravel a variety of mechanisms and molecular players that contribute to FA turnover, beyond microtubules. Here, we discuss recent discoveries of key molecular players that affect the dynamics and organization of the actin cytoskeleton to enable timely FA turnover and consequently proper directed cell migration.",

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The compass to follow: Focal adhesion turnover

Abstract

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