The compass to follow: Focal adhesion turnover

Manos Mavrakis, M. Angeles Juanes

Research output: Contribution to journalReview articlepeer-review

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Abstract

How cells move is a fundamental biological question. The directionality of adherent migrating cells depends on the assembly and disassembly (turnover) of focal adhesions (FAs). FAs are micron-sized actin-based structures that link cells to the extracellular matrix. Traditionally, microtubules have been considered key to triggering FA turnover. Through the years, advancements in biochemistry, biophysics, and bioimaging tools have been invaluable for many research groups to unravel a variety of mechanisms and molecular players that contribute to FA turnover, beyond microtubules. Here, we discuss recent discoveries of key molecular players that affect the dynamics and organization of the actin cytoskeleton to enable timely FA turnover and consequently proper directed cell migration.

Original languageEnglish
Article number102152
Number of pages17
JournalCurrent Opinion in Cell Biology
Volume80
DOIs
Publication statusPublished - 1 Feb 2023

Bibliographical note

Funding Information:
This work was supported by grants from the Academy of Medical Science (AMS), Wellcome Trust/the Government Department of Business, Energy and Industrial Strategy/the British Heart Foundation/Diabetes UK, AMS Springboard Award (UK) [ SBF006\1070 ]; and the CIDEGENT Excellent Research Program of the Valencian Regional government (Spain) CIDEGENT/2021/026 to M.A.J.

Publisher Copyright:
© 2023 The Author(s)

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