Previous research has suggested that individuals’ resolution of temporal ambiguity relies on experiences in physical domains, as well as on future event valence and emotional experiences. In the current study, we investigate whether the interpretation of a temporally ambiguous question is modulated by the day of the week on which the study was conducted. We asked participants (N = 208) to resolve the ambiguous time question on different days of the week (Monday or Friday). The results of the experiment indicate differences in processing of temporal ambiguity between different days of the week. The study raises the interesting possibility that days of the week can have important implications for resolving temporal ambiguity.