The final cut: cell polarity meets cytokinesis at the bud neck in S. cerevisiae

Maria Angeles Juanes, Simonetta Piatti

    Research output: Contribution to journalReview articlepeer-review

    16 Citations (Scopus)

    Abstract

    Cell division is a fundamental but complex process that gives rise to two daughter cells. It includes an ordered set of events, altogether called “the cell cycle”, that culminate with cytokinesis, the final stage of mitosis leading to the physical separation of the two daughter cells. Symmetric cell division equally partitions cellular components between the two daughter cells, which are therefore identical to one another and often share the same fate. In many cases, however, cell division is asymmetrical and generates two daughter cells that differ in specific protein inheritance, cell size, or developmental potential. The budding yeast Saccharomyces cerevisiae has proven to be an excellent system to investigate the molecular mechanisms governing asymmetric cell division and cytokinesis. Budding yeast is highly polarized during the cell cycle and divides asymmetrically, producing two cells with distinct sizes and fates. Many components of the machinery establishing cell polarization during budding are relocalized to the division site (i.e., the bud neck) for cytokinesis. In this review we recapitulate how budding yeast cells undergo polarized processes at the bud neck for cell division.

    Original languageEnglish
    Pages (from-to)3115-3136
    Number of pages22
    JournalCellular and Molecular Life Sciences
    Volume73
    Issue number16
    Early online date16 Apr 2016
    DOIs
    Publication statusPublished - 1 Aug 2016

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