The mechanism of decomposition of N-methyl-N-nitrosourea in aqueous solution according to 13C and 15N NMR studies: Quantitative fragmentation to cyanate

Christine Bleasdale, Bernard T. Golding, Joseph McGinnis, Susanna Müller, William P. Watson

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    The use of 13C NMR spectroscopy to monitor the decomposition of [13CO]N-methyl-N-nitrosourea, and of 15N NMR spectroscopy to follow the decomposition of [15NH2]N-methyl-N- nitrosourea, both in aqueous phosphate buffer at pH 7, shows the initial product to be cyanate rather than carbamate; the cyanate reacts with phosphate to give carbamoyl phosphate.

    Original languageEnglish
    Pages (from-to)1726-1728
    Number of pages3
    JournalJournal of the Chemical Society, Chemical Communications
    Issue number24
    DOIs
    Publication statusPublished - 1 Dec 1991

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