The mechanism of decomposition of N-methyl-N-nitrosourea in aqueous solution according to 13C and 15N NMR studies: Quantitative fragmentation to cyanate

Christine Bleasdale; Bernard T. Golding; Joseph McGinnis; Susanna Müller; William P. Watson

doi:10.1039/C39910001726

The mechanism of decomposition of N-methyl-N-nitrosourea in aqueous solution according to ¹³C and ¹⁵N NMR studies: Quantitative fragmentation to cyanate

Christine Bleasdale
, Bernard T. Golding
, Joseph McGinnis
, Susanna Müller
, William P. Watson

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The use of ¹³C NMR spectroscopy to monitor the decomposition of [¹³CO]N-methyl-N-nitrosourea, and of ¹⁵N NMR spectroscopy to follow the decomposition of [¹⁵NH₂]N-methyl-N- nitrosourea, both in aqueous phosphate buffer at pH 7, shows the initial product to be cyanate rather than carbamate; the cyanate reacts with phosphate to give carbamoyl phosphate.

Original language	English
Pages (from-to)	1726-1728
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	24
DOIs	https://doi.org/10.1039/C39910001726
Publication status	Published - 1 Dec 1991

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10.1039/C39910001726

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title = "The mechanism of decomposition of N-methyl-N-nitrosourea in aqueous solution according to 13C and 15N NMR studies: Quantitative fragmentation to cyanate",

abstract = "The use of 13C NMR spectroscopy to monitor the decomposition of [13CO]N-methyl-N-nitrosourea, and of 15N NMR spectroscopy to follow the decomposition of [15NH2]N-methyl-N- nitrosourea, both in aqueous phosphate buffer at pH 7, shows the initial product to be cyanate rather than carbamate; the cyanate reacts with phosphate to give carbamoyl phosphate.",

author = "Christine Bleasdale and Golding, \{Bernard T.\} and Joseph McGinnis and Susanna M{\"u}ller and Watson, \{William P.\}",

year = "1991",

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language = "English",

pages = "1726--1728",

journal = "Journal of the Chemical Society, Chemical Communications",

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The mechanism of decomposition of N-methyl-N-nitrosourea in aqueous solution according to ¹³C and ¹⁵N NMR studies: Quantitative fragmentation to cyanate. / Bleasdale, Christine; Golding, Bernard T.; McGinnis, Joseph et al.
In: Journal of the Chemical Society, Chemical Communications, No. 24, 01.12.1991, p. 1726-1728.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The mechanism of decomposition of N-methyl-N-nitrosourea in aqueous solution according to 13C and 15N NMR studies

T2 - Quantitative fragmentation to cyanate

AU - Bleasdale, Christine

AU - Golding, Bernard T.

AU - McGinnis, Joseph

AU - Müller, Susanna

AU - Watson, William P.

PY - 1991/12/1

Y1 - 1991/12/1

N2 - The use of 13C NMR spectroscopy to monitor the decomposition of [13CO]N-methyl-N-nitrosourea, and of 15N NMR spectroscopy to follow the decomposition of [15NH2]N-methyl-N- nitrosourea, both in aqueous phosphate buffer at pH 7, shows the initial product to be cyanate rather than carbamate; the cyanate reacts with phosphate to give carbamoyl phosphate.

AB - The use of 13C NMR spectroscopy to monitor the decomposition of [13CO]N-methyl-N-nitrosourea, and of 15N NMR spectroscopy to follow the decomposition of [15NH2]N-methyl-N- nitrosourea, both in aqueous phosphate buffer at pH 7, shows the initial product to be cyanate rather than carbamate; the cyanate reacts with phosphate to give carbamoyl phosphate.

UR - https://www.scopus.com/pages/publications/0026327993

U2 - 10.1039/C39910001726

DO - 10.1039/C39910001726

M3 - Article

AN - SCOPUS:0026327993

SN - 0022-4936

SP - 1726

EP - 1728

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 24

ER -

The mechanism of decomposition of N-methyl-N-nitrosourea in aqueous solution according to ¹³C and ¹⁵N NMR studies: Quantitative fragmentation to cyanate

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