The physiological properties of the decompensated, spinal cord injured bladder

John S. Young; Louise Johnston; Gordon McMurray; Rachel Eccles; Karen D. McCloskey; Christopher H. Fry

Abstract

Hypothesis / aims of study
Urinary retention is a significant clinical problem with a complex morbidity and is associated with bladder obstruction or
neurological deficits. Retention is associated with high or low detrusor pressures [1], as co-morbidites such as urinary tract
infections and more serious consequences such as renal failure are present, especially if pressure is high. However, low
pressure retention is less amenable to surgical correction and persists longer. Voiding is difficult in the low pressure group and
is commonly attributed to reduced detrusor contractility [1,2]. However the pathogenesis of low-pressure retention is unknown
and it is important to determine if it is failure of muscle contractility or a remodelling of tissues within the bladder wall. The aim
of this study was to address this question in a rat model where bladder obstruction through spinal cord injury was utilised to
generate a large, low-pressure bladder.

Original language	English
Number of pages	4
Publication status	Published - 31 Aug 2011
Externally published	Yes
Event	ICS 2011 - Glasgow, United Kingdom Duration: 29 Aug 2011 → 2 Sept 2011 https://www.ics.org/2011

Conference

Conference	ICS 2011
Country/Territory	United Kingdom
City	Glasgow
Period	29/08/11 → 2/09/11
Internet address	https://www.ics.org/2011

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https://www.ics.org/2011/abstract/95Licence: Unspecified

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title = "The physiological properties of the decompensated, spinal cord injured bladder",

abstract = "Hypothesis / aims of studyUrinary retention is a significant clinical problem with a complex morbidity and is associated with bladder obstruction orneurological deficits. Retention is associated with high or low detrusor pressures [1], as co-morbidites such as urinary tractinfections and more serious consequences such as renal failure are present, especially if pressure is high. However, lowpressure retention is less amenable to surgical correction and persists longer. Voiding is difficult in the low pressure group andis commonly attributed to reduced detrusor contractility [1,2]. However the pathogenesis of low-pressure retention is unknownand it is important to determine if it is failure of muscle contractility or a remodelling of tissues within the bladder wall. The aimof this study was to address this question in a rat model where bladder obstruction through spinal cord injury was utilised togenerate a large, low-pressure bladder.",

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T1 - The physiological properties of the decompensated, spinal cord injured bladder

AU - Young, John S.

AU - Johnston, Louise

AU - McMurray, Gordon

AU - Eccles, Rachel

AU - McCloskey, Karen D.

AU - Fry, Christopher H.

PY - 2011/8/31

Y1 - 2011/8/31

N2 - Hypothesis / aims of studyUrinary retention is a significant clinical problem with a complex morbidity and is associated with bladder obstruction orneurological deficits. Retention is associated with high or low detrusor pressures [1], as co-morbidites such as urinary tractinfections and more serious consequences such as renal failure are present, especially if pressure is high. However, lowpressure retention is less amenable to surgical correction and persists longer. Voiding is difficult in the low pressure group andis commonly attributed to reduced detrusor contractility [1,2]. However the pathogenesis of low-pressure retention is unknownand it is important to determine if it is failure of muscle contractility or a remodelling of tissues within the bladder wall. The aimof this study was to address this question in a rat model where bladder obstruction through spinal cord injury was utilised togenerate a large, low-pressure bladder.

AB - Hypothesis / aims of studyUrinary retention is a significant clinical problem with a complex morbidity and is associated with bladder obstruction orneurological deficits. Retention is associated with high or low detrusor pressures [1], as co-morbidites such as urinary tractinfections and more serious consequences such as renal failure are present, especially if pressure is high. However, lowpressure retention is less amenable to surgical correction and persists longer. Voiding is difficult in the low pressure group andis commonly attributed to reduced detrusor contractility [1,2]. However the pathogenesis of low-pressure retention is unknownand it is important to determine if it is failure of muscle contractility or a remodelling of tissues within the bladder wall. The aimof this study was to address this question in a rat model where bladder obstruction through spinal cord injury was utilised togenerate a large, low-pressure bladder.

UR - https://researchportal.port.ac.uk/en/publications/829310c0-a22f-4a2d-9db0-a825b7ab4eeb

M3 - Abstract

T2 - ICS 2011

Y2 - 29 August 2011 through 2 September 2011

ER -

The physiological properties of the decompensated, spinal cord injured bladder

Abstract

Conference

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