Ageing can be classiﬁed in two diﬀerent ways, chronological ageing and biological ageing. While chronological age is a measure of the time that has passed since birth, biological (also known as transcriptomic) ageing is deﬁned by how time and the environment aﬀect an individual in comparison to other individuals of the same chronological age. Recent research studies have shown that transcriptomic age is associated with certain genes, and that each of those genes has an eﬀect size. Using these eﬀect sizes we can calculate the transcriptomic age of an individual from their age-associated gene expression levels. The limitation of this approach is that it does not consider how these changes in gene expression aﬀect the metabolism of individuals and hence their observable cellular phenotype.
- Centre for Digital Innovation
- School of Computing, Engineering & Digital Technologies
- Department of Computing & Games - Principal Lecturer in Computer Science
Person: Doctor of Philosophy, Academic