The use of click chemistry in the emerging field of catalomics

Karunakaran A. Kalesh, Haibin Shi, Jingyan Ge, Shao Q. Yao

Research output: Contribution to journalArticlepeer-review


Of the thousands of known chemical reactions, a handful of reactions, called “click” reactions, stand out with features such as good chemoselectivity, good solvent compatibilities, modularity, minimum synthetic demands, bioorthogonality and high yields. Among them, the Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction between azides and terminal alkynes has emerged as a powerful tool in chemical biology and proteomics. This perspective surveys the significant contributions of click chemistry in catalomics (a sub-area in chemical proteomics), with special emphasis on activity-based protein profiling (ABPP), posttranslational modifications (PTMs) and enzyme inhibitor developments.
Original languageEnglish
Pages (from-to)1749-1762
Number of pages14
JournalOrganic & Biomolecular Chemistry
Publication statusPublished - 11 Feb 2010
Externally publishedYes


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