The use of recently described ionisation techniques for the rapid analysis of some common drugs and samples of biological origin

Jonathan P. Williams, Vibhuti J. Patel, Richard Holland, James Scrivens

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156 Citations (Scopus)

Abstract

Three ionisation techniques that require no sample preparation or extraction prior to mass analysis have been used for the rapid analysis of pharmaceutical tablets and ointments. These methods were (i) the novel direct analysis in real time (DART), (ii) desorption electrospray ionisation (DESI), and (iii) desorption atmospheric pressure chemical ionisation (DAPCI). The performance of the three techniques was investigated for a number of common drugs. Significant differences between these approaches were observed. For compounds of moderate to low polarity DAPCI produced more effective ionisation. Accurate DESI and DAPCI tandem mass spectra were obtained and these greatly enhance the selectivity and information content of the experiment. The detection from human skin of the active ingredients from ointments is reported together with the detection of ibuprofen metabolites in human urine.

Original languageEnglish
Pages (from-to)1447-1456
Number of pages10
JournalRapid Communications in Mass Spectrometry
Volume20
Issue number9
DOIs
Publication statusPublished - 9 May 2006

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Ionization
Desorption
Atmospheric pressure
Electrospray ionization
Pharmaceutical Preparations
Ointments
Ibuprofen
Metabolites
Tablets
Skin
Experiments

Cite this

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abstract = "Three ionisation techniques that require no sample preparation or extraction prior to mass analysis have been used for the rapid analysis of pharmaceutical tablets and ointments. These methods were (i) the novel direct analysis in real time (DART), (ii) desorption electrospray ionisation (DESI), and (iii) desorption atmospheric pressure chemical ionisation (DAPCI). The performance of the three techniques was investigated for a number of common drugs. Significant differences between these approaches were observed. For compounds of moderate to low polarity DAPCI produced more effective ionisation. Accurate DESI and DAPCI tandem mass spectra were obtained and these greatly enhance the selectivity and information content of the experiment. The detection from human skin of the active ingredients from ointments is reported together with the detection of ibuprofen metabolites in human urine.",
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The use of recently described ionisation techniques for the rapid analysis of some common drugs and samples of biological origin. / Williams, Jonathan P.; Patel, Vibhuti J.; Holland, Richard; Scrivens, James .

In: Rapid Communications in Mass Spectrometry, Vol. 20, No. 9, 09.05.2006, p. 1447-1456.

Research output: Contribution to journalArticleResearchpeer-review

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