Trichodermaketones A-D and 7-O-methylkoninginin D from the marine fungus Trichoderma koningii

Fuhang Song, Huanqin Dai, Yaojun Tong, Biao Ren, Caixia Chen, Nuo Sun, Xiangyang Liu, Jiang Bian, Mei Liu, Hong Gao, Hongwei Liu, Xiaoping Chen, Lixin Zhang

    Research output: Contribution to journalArticlepeer-review


    Five new polyketide derivatives, 7-O-methylkoninginin D (1) and trichodermaketones A-D (2-5), together with four known compounds, koninginins A, D, E, and F, were isolated from the marine-derived fungus Trichoderma koningii. Trichodermaketones A (2) and B (3) are unprecedented polyketides with a bistetrafuran-containing tricyclic skeleton. The chemical structures and absolute configurations of compounds 1-5 were elucidated by comparing with literature data and extensive spectroscopic methods, including 2D NMR and CD spectroscopic analysis. Compounds 1-5 were evaluated for action against bacteria and fungi and for synergistic antifungal activity. Compound 2 showed synergistic antifungal activity against Candida albicans with 0.05 microg/mL ketoconazole.

    Original languageEnglish
    Pages (from-to)806-10
    Number of pages5
    JournalJournal of Natural Products
    Issue number5
    Publication statusPublished - 28 May 2010


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