Abstract
Hepatitis viral infections are the most common cause of hepatitis liver disease, which eventually leads to cancer and fibrosis if undetected early. Therefore, early detection would allow for preventive and therapeutic actions. Here, a surface-enhanced Raman spectroscopy (SERS)-based biosensor was developed using plasmonic molybdenum trioxide quantum dots (MoO3-QDs) as the
SERS substrates. The nanostructured substrate of MoO3-QDs was functionalized with a proteoglycan (Syndecan-1) as a novel bioreceptor for target hepatitis E virus (HEV). The innovative bio-detection system achieved a detection limit of 1.05 fg/mL for tested HEV target (ORF2), indicating superb clinically relevant sensitivity and performance. The designed biosensing system incorporating a glycan motif as a bioreceptor instead of the conventional antibodies or aptamers,
presents new insights for the ultrasensitive detection of HEV and other infectious viruses.
SERS substrates. The nanostructured substrate of MoO3-QDs was functionalized with a proteoglycan (Syndecan-1) as a novel bioreceptor for target hepatitis E virus (HEV). The innovative bio-detection system achieved a detection limit of 1.05 fg/mL for tested HEV target (ORF2), indicating superb clinically relevant sensitivity and performance. The designed biosensing system incorporating a glycan motif as a bioreceptor instead of the conventional antibodies or aptamers,
presents new insights for the ultrasensitive detection of HEV and other infectious viruses.
| Original language | English |
|---|---|
| Article number | 2 |
| Journal | Eng. Proceedings |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 7 Oct 2023 |
| Event | The 2nd International Electronic Conference on Chemical Sensors and Analytical Chemistry - Online Duration: 16 Sept 2023 → 30 Sept 2023 https://csac2023.sciforum.net/ |