Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways

Shi Tian; Meet Zandawala; Isabel Beets; Esra Baytemur; Susan E. Slade; James Scrivens; Maurice R. Elphick

doi:10.1038/srep28788

Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways

Shi Tian, Meet Zandawala, Isabel Beets, Esra Baytemur, Susan E. Slade, James Scrivens, Maurice R. Elphick

Centre for Biodiscovery

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Abstract

Gonadotropin-releasing hormone (GnRH) is a key regulator of reproductive maturation in humans and other vertebrates. Homologs of GnRH and its cognate receptor have been identified in invertebrates–for example, the adipokinetic hormone (AKH) and corazonin (CRZ) neuropeptide pathways in arthropods. However, the precise evolutionary relationships and origins of these signalling systems remain unknown. Here we have addressed this issue with the first identification of both GnRH-type and CRZ-type signalling systems in a deuterostome–the echinoderm (starfish) Asterias rubens. We have identified a GnRH-like neuropeptide (pQIHYKNPGWGPG-NH2) that specifically activates an A. rubens GnRH-type receptor and a novel neuropeptide (HNTFTMGGQNRWKAG-NH2) that specifically activates an A. rubens CRZ-type receptor. With the discovery of these ligand-receptor pairs, we demonstrate that the vertebrate/deuterostomian GnRH-type and the protostomian AKH systems are orthologous and the origin of a paralogous CRZ-type signalling system can be traced to the common ancestor of the Bilateria (Urbilateria).

Original language	English
Article number	28788 (2016)
Pages (from-to)	-
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep28788
Publication status	Published - 28 Jun 2016

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https://doi.org/10.1038/srep28788Licence: CC BY

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title = "Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways",

abstract = "Gonadotropin-releasing hormone (GnRH) is a key regulator of reproductive maturation in humans and other vertebrates. Homologs of GnRH and its cognate receptor have been identified in invertebrates–for example, the adipokinetic hormone (AKH) and corazonin (CRZ) neuropeptide pathways in arthropods. However, the precise evolutionary relationships and origins of these signalling systems remain unknown. Here we have addressed this issue with the first identification of both GnRH-type and CRZ-type signalling systems in a deuterostome–the echinoderm (starfish) Asterias rubens. We have identified a GnRH-like neuropeptide (pQIHYKNPGWGPG-NH2) that specifically activates an A. rubens GnRH-type receptor and a novel neuropeptide (HNTFTMGGQNRWKAG-NH2) that specifically activates an A. rubens CRZ-type receptor. With the discovery of these ligand-receptor pairs, we demonstrate that the vertebrate/deuterostomian GnRH-type and the protostomian AKH systems are orthologous and the origin of a paralogous CRZ-type signalling system can be traced to the common ancestor of the Bilateria (Urbilateria).",

author = "Shi Tian and Meet Zandawala and Isabel Beets and Esra Baytemur and Slade, {Susan E.} and James Scrivens and Elphick, {Maurice R.}",

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T1 - Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways

AU - Tian, Shi

AU - Zandawala, Meet

AU - Beets, Isabel

AU - Baytemur, Esra

AU - Slade, Susan E.

AU - Scrivens, James

AU - Elphick, Maurice R.

PY - 2016/6/28

Y1 - 2016/6/28

N2 - Gonadotropin-releasing hormone (GnRH) is a key regulator of reproductive maturation in humans and other vertebrates. Homologs of GnRH and its cognate receptor have been identified in invertebrates–for example, the adipokinetic hormone (AKH) and corazonin (CRZ) neuropeptide pathways in arthropods. However, the precise evolutionary relationships and origins of these signalling systems remain unknown. Here we have addressed this issue with the first identification of both GnRH-type and CRZ-type signalling systems in a deuterostome–the echinoderm (starfish) Asterias rubens. We have identified a GnRH-like neuropeptide (pQIHYKNPGWGPG-NH2) that specifically activates an A. rubens GnRH-type receptor and a novel neuropeptide (HNTFTMGGQNRWKAG-NH2) that specifically activates an A. rubens CRZ-type receptor. With the discovery of these ligand-receptor pairs, we demonstrate that the vertebrate/deuterostomian GnRH-type and the protostomian AKH systems are orthologous and the origin of a paralogous CRZ-type signalling system can be traced to the common ancestor of the Bilateria (Urbilateria).

AB - Gonadotropin-releasing hormone (GnRH) is a key regulator of reproductive maturation in humans and other vertebrates. Homologs of GnRH and its cognate receptor have been identified in invertebrates–for example, the adipokinetic hormone (AKH) and corazonin (CRZ) neuropeptide pathways in arthropods. However, the precise evolutionary relationships and origins of these signalling systems remain unknown. Here we have addressed this issue with the first identification of both GnRH-type and CRZ-type signalling systems in a deuterostome–the echinoderm (starfish) Asterias rubens. We have identified a GnRH-like neuropeptide (pQIHYKNPGWGPG-NH2) that specifically activates an A. rubens GnRH-type receptor and a novel neuropeptide (HNTFTMGGQNRWKAG-NH2) that specifically activates an A. rubens CRZ-type receptor. With the discovery of these ligand-receptor pairs, we demonstrate that the vertebrate/deuterostomian GnRH-type and the protostomian AKH systems are orthologous and the origin of a paralogous CRZ-type signalling system can be traced to the common ancestor of the Bilateria (Urbilateria).

U2 - 10.1038/srep28788

DO - 10.1038/srep28788

M3 - Article

SN - 2045-2322

VL - 6

SP - -

JO - Scientific Reports

JF - Scientific Reports

M1 - 28788 (2016)

ER -

Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways

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