Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome

Max Crispin, David J. Harvey, David Bitto, Steinar Halldorsson, Camille Bonomelli, Matthew Edgeworth, James Scrivens, Juha T. Huiskonen, Thomas A. Bowden

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    Abstract

    Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.
    Original languageEnglish
    Pages (from-to)10244-10251
    JournalJournal of Virology
    Volume88
    Issue number17
    DOIs
    Publication statusPublished - 18 Jun 2014

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