Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome

Max Crispin; David J. Harvey; David Bitto; Steinar Halldorsson; Camille Bonomelli; Matthew Edgeworth; James Scrivens; Juha T. Huiskonen; Thomas A. Bowden

doi:10.1128/JVI.01662-14

Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome

Max Crispin, David J. Harvey, David Bitto, Steinar Halldorsson, Camille Bonomelli, Matthew Edgeworth, James Scrivens, Juha T. Huiskonen, Thomas A. Bowden

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Abstract

Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.

Original language	English
Pages (from-to)	10244-10251
Journal	Journal of Virology
Volume	88
Issue number	17
DOIs	https://doi.org/10.1128/JVI.01662-14
Publication status	Published - 18 Jun 2014

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10.1128/JVI.01662-14Licence: Other

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title = "Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome",

abstract = "Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.",

author = "Max Crispin and Harvey, \{David J.\} and David Bitto and Steinar Halldorsson and Camille Bonomelli and Matthew Edgeworth and James Scrivens and Huiskonen, \{Juha T.\} and Bowden, \{Thomas A.\}",

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T1 - Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome

AU - Crispin, Max

AU - Harvey, David J.

AU - Bitto, David

AU - Halldorsson, Steinar

AU - Bonomelli, Camille

AU - Edgeworth, Matthew

AU - Scrivens, James

AU - Huiskonen, Juha T.

AU - Bowden, Thomas A.

PY - 2014/6/18

Y1 - 2014/6/18

N2 - Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.

AB - Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.

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DO - 10.1128/JVI.01662-14

M3 - Article

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VL - 88

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EP - 10251

JO - Journal of Virology

JF - Journal of Virology

IS - 17

ER -

Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome

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