Validating the stroke-thrombolytic predictive instrument in a population in the United Kingdom

Peter McMeekin, Darren Flynn, Gary A. Ford, Helen Rodgers, Richard G. Thomson

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Background and Purpose: This study aimed to test the explanatory qualities of the Stroke-Thrombolytic Predictive Instrument (S-TPI) when applied to patients treated in routine practice. Methods: S-TPI predictions were compared with observed outcomes in terms of normal/near-normal (modified Rankin Scale score, ≤1) and catastrophic outcome (modified Rankin Scale score, ≥5) at 3 months. Logistic regression was used to calibrate and expand the S-TPI. Results: The S-TPI overestimated probability of catastrophic outcomes and overestimated the probability of a normal/near normal outcome above 0.4 and underestimated those below. Calibrating the S-TPI minimized discrepancies between predicted and observed outcomes, in the case of normal/near-normal outcomes, where including additional predictors (serum glucose and signs of current infarction on pretreatment brain scan) further reduced discrepancies between predicted and observed outcomes. Conclusions: The explanatory power of the S-TPI in thrombolytic-treated patients can be improved to reflect outcomes seen in routine practice.

    Original languageEnglish
    Pages (from-to)3378-3381
    Number of pages4
    JournalStroke
    Volume43
    Issue number12
    DOIs
    Publication statusPublished - 1 Dec 2012

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