Validating the stroke-thrombolytic predictive instrument in a population in the United Kingdom

Peter McMeekin, Darren Flynn, Gary A. Ford, Helen Rodgers, Richard G. Thomson

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Background and Purpose: This study aimed to test the explanatory qualities of the Stroke-Thrombolytic Predictive Instrument (S-TPI) when applied to patients treated in routine practice. Methods: S-TPI predictions were compared with observed outcomes in terms of normal/near-normal (modified Rankin Scale score, ≤1) and catastrophic outcome (modified Rankin Scale score, ≥5) at 3 months. Logistic regression was used to calibrate and expand the S-TPI. Results: The S-TPI overestimated probability of catastrophic outcomes and overestimated the probability of a normal/near normal outcome above 0.4 and underestimated those below. Calibrating the S-TPI minimized discrepancies between predicted and observed outcomes, in the case of normal/near-normal outcomes, where including additional predictors (serum glucose and signs of current infarction on pretreatment brain scan) further reduced discrepancies between predicted and observed outcomes. Conclusions: The explanatory power of the S-TPI in thrombolytic-treated patients can be improved to reflect outcomes seen in routine practice.

Original languageEnglish
Pages (from-to)3378-3381
Number of pages4
JournalStroke
Volume43
Issue number12
DOIs
Publication statusPublished - 1 Dec 2012

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Stroke
Population
Infarction
United Kingdom
Logistic Models
Glucose
Brain
Serum

Cite this

McMeekin, Peter ; Flynn, Darren ; Ford, Gary A. ; Rodgers, Helen ; Thomson, Richard G. / Validating the stroke-thrombolytic predictive instrument in a population in the United Kingdom. In: Stroke. 2012 ; Vol. 43, No. 12. pp. 3378-3381.
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Validating the stroke-thrombolytic predictive instrument in a population in the United Kingdom. / McMeekin, Peter; Flynn, Darren; Ford, Gary A.; Rodgers, Helen; Thomson, Richard G.

In: Stroke, Vol. 43, No. 12, 01.12.2012, p. 3378-3381.

Research output: Contribution to journalArticleResearchpeer-review

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